What is tocilizumab and how is it used?

Tocilizumab is a biological therapy and can be prescribed for rheumatoid arthritis (roo-ma-toy-d arth-ri-tus), juvenile idiopathic arthritis (JIA) or giant cell arteritis.

If you have rheumatoid arthritis, or another autoimmune or inflammatory condition, there may be too much of the IL-6 protein in your body. This can cause inflammation and damage, and in children can cause a fever and rashes. Tocilizumab works by blocking the effects of IL-6.

Tocilizumab will work within three to six months, if it is going to work at all. Some patients may feel better as early as two weeks after starting treatment.

It may be the first biological therapy you’re given, or you may have tried others first, such as an anti-TNF treatment or rituximab.

You won’t be given tocilizumab if:

  • your arthritis isn’t active
  • you have a severe infection
  • you have not tried other treatments for your condition
  • you’re pregnant or breastfeeding.

Your doctor may decide not to prescribe tocilizumab if:

  • you keep getting infections
  • you’ve had liver disease or if blood tests suggest that the drug may affect your liver
  • you have a low number of white blood cells or platelets
  • you have a history of diverticulitis (die-vuh-tick-yoo-lie-tus)
  • you have certain heart problems.

There’s no good evidence that using tocilizumab to control your immune system increases your risk of cancer. Even so, if you’ve had cancer before, you should always let your clinical team know in case this affects decisions about your treatment.

Your doctor will check whether you’ve previously been exposed to tuberculosis (TB). You may need a course of treatment for latent TB before starting tocilizumab. However, this may not be done if you’re a child with systemic onset JIA.

If you’re an adult, you will also be screened for hepatitis B and C infection. Tocilizumab may increase the risk of hepatitis B starting up again, although very few cases have been reported. If you have a history of hepatitis, the decision to use tocilizumab may involve a discussion between you, your rheumatologist (roo-ma-tolo-jist) and a liver doctor.

If you’re an adult, you may have a chest x-ray before starting tocilizumab. You will also have a chest x-ray six months after starting treatment.

How is it taken?

How to take tocilizumab

  Rheumatoid arthritis Giant cell arteritis Systemic JIA Polyarticular JIA
Subcutaneous injection Yes – this is done once a week Yes – once a week, in the thigh or upper arm Yes, if aged 12 or over; once a week or once every 2 weeks depending on body weight Yes, if aged 12 or over; once every 2 or 3 weeks depending on body weight
Intravenous infusion Yes – this takes about an hour once every four weeks No Yes – every two weeks Yes – every four weeks

An intravenous (in-truh-vee-nus) infusion is when the drug is given through a drip into a vein.

A subcutaneous (sub-kyoo-tay-nee-us) injection is when the drug is injected under the skin, using a pre-filled syringe or a pen device.

If you’re already having infusions and want to switch to injections, speak to your rheumatology team.

Because it’s a long-term treatment, it’s important to keep taking tocilizumab:

  • even if it doesn’t seem to be working at first
  • even when your symptoms start to improve, as this will help keep your condition under control.

However, this may change if you experience side effects.

Side-effects and risks

The most common side effects are:

  • a cough or sore throat, blocked or runny nose
  • headaches or dizziness
  • mouth ulcers
  • high blood pressure
  • hypercholesterolaemia (increased cholesterol in the blood)
  • allergic reactions - this can include aching muscles, feeling out of breath, having a tight chest, wheezing, and a high temperature
  • weight gain or swollen ankles
  • skin rashes, infections or itching
  • stomach irritation or abdominal pain.

Tocilizumab has been shown to increase the risk of infections in patients with rheumatoid arthritis. These include:

  • upper respiratory tract infections
  • cold sores
  • shingles
  • skin infections - such as cellulitis (sel-lyu-lie-tus)
  • pneumonia (new-mow-nee-uh).

It is important that any infections are treated as soon as possible.

If you think you may have an infection, or you become unwell in any way, contact your rheumatology team or your GP. People taking tocilizumab do not always display the usual signs of infection, such as a high temperature, as they are blocked by tocilizumab. Seek advice if you’re unsure.

If you’re prescribed antibiotics, speak to your rheumatology team and cancel your tocilizumab infusion. Temporarily stop your injections until the infection has cleared up.

If you’re living with HIV, hepatitis B or hepatitis C, it is important that you discuss any potential risks of taking tocilizumab with your rheumatologist.

Cholesterol and liver function

Tocilizumab can increase your cholesterol levels and can also affect liver function tests. As a result, you will need a blood test every four weeks while taking tocilizumab.


You may feel dizzy while taking tocilizumab. This could affect your ability to drive and perform other tasks.

Effects on other treatments

Tocilizumab may be prescribed along with other drugs, including methotrexate (mee-thoh-treks-ate) and glucocorticoids (steroids). Check with your doctor before starting any new medications, and remember to mention you’re on tocilizumab if you’re treated by anyone other than your usual rheumatology team.

In rheumatoid arthritis

Tocilizumab can be taken for rheumatoid arthritis if:

  • your arthritis is severe
  • your arthritis has not responded to intensive therapy with a combination of conventional DMARDs.

Usually tocilizumab is prescribed in combination with methotrexate, but it can be used on its own if you’re unable to take methotrexate.

In giant cell arteritis

Tocilizumab is recommended as an option for treating giant cell arteritis in adults if used with steroids that are gradually decreased. It can also be used by itself after glucocorticoids have been stopped. However, this is only the case if:

  • you have a condition that has not responded to steroids by themselves, or has relapsed after having treatment with steroids
  • you have not already received tocilizumab for your giant cell arteritis.

Tocilizumab should not be continued for more than one year in people with giant cell arteritis.

It’s recommended that you carry a biological therapy alert card, so that anyone treating you will know you’re on tocilizumab. You can get a card from your rheumatology department.


There’s no particular reason to avoid alcohol while taking tocilizumab. However, the government guidelines say that both men and women should drink no more than 14 units of alcohol a week, and that you should spread these through the week rather than having them all in one go.

You can find out more about units of alcohol at


It’s usually recommended that people on tocilizumab avoid the following live vaccines:

  • yellow fever
  • varicella-zoster (varry-sell-er zos-ter)
  • typhoid
  • rotavirus
  • MMR (measles, mumps and rubella)
  • BCG.

If you're already on tocilizumab, speak to your doctor before having any of the above vaccinations. Sometimes a live vaccine may be necessary, such as rubella vaccination in women of child-bearing age.

The Zostavax shingles vaccine is a live vaccine and isn’t recommended for people who are on tocilizumab. However, a non-live shingles vaccine (Shingrix) is available so you may be able to have this instead.

Pneumococcal (new-mo-cock-all) vaccine, which protects against the most common cause of pneumonia, and yearly flu vaccines, are safe and recommended.

Where possible, any routine vaccinations for children should be given before starting tocilizumab.

Having an operation

If you take tocilizumab intravenously, it should be stopped at least four weeks before surgery. If you take tocilizumab subcutaneously (by injection or injection pen), it should be stopped at least two weeks before surgery.

Speak to your healthcare team for more details.

Fertility, pregnancy and breastfeeding

If you’re planning to try for a baby, if you become pregnant or if you’re thinking of breastfeeding, talk to your rheumatologist.

Tocilizumab should be avoided during pregnancy, unless essential, as it’s not yet known how the drug can affect an unborn baby.

If you’ve taken tocilizumab in the early stages of a pregnancy, it’s unlikely to be harmful.

You should be OK to breastfeed while taking tocilizumab, but the research is limited so it would be a good idea to talk to your doctor about this.

There is currently no evidence that men must stop tocilizumab if they are trying to father a baby.