Osteoarthritis - A clinical trial of denosumab in patients with knee osteoarthritis
Learn about our research into whether denosumab, which treats osteoporosis, can reduce the severity of knee pain and bone marrow changes in patients with OA.
Live research projects
Osteoarthritis - A first-in-human study to test a scaffold treatment for early osteoarthritis
Learn about our research into the safety and suitability of treating early knee osteoarthritis using a scaffold type device instead of a joint replacement.
Osteoarthritis - Biomarkers and joint pain in military osteoarthritis study
Learn about our research into risk markers for osteoarthritis development in military personnel exposed to trauma, allowing us to predict who will develop OA.
Osteoarthritis - Biomechanics and Bioengineering Research Centre Versus Arthritis
Learn about our Biomechanics and Bioengineering Research Centre, where experts apply engineering solutions and basic science to problems caused by arthritis.
Osteoarthritis - Can personalised, 3D printed surgical guides improve outcomes of high tibial osteotomy (HTO)?
Learn about our research to trial ‘Tailored Osteotomy for Knee Alignment’ (ToKa), with 3D printed surgical guides and plates, to see if it improves correction.
Osteoarthritis - Can we identify biological markers in joint fluid to predict progression of knee osteoarthritis?
Learn more about if can we identify biological markers in joint fluid to predict progression of knee osteoarthritis.
Osteoarthritis - Can we identify markers to predict which treatments people with knee cartilage damage will respond best to?
Learn more about if we can we identify markers to predict which treatments people with knee cartilage damage will respond best to?
Osteoarthritis - Can we make arthritis surgery better and safer for patients by training surgeons using donated human bodies?
Read more about if we can make arthritis surgery better and safer for patients by training surgeons using donated human bodies?
Osteoarthritis - Can we predict risk of knee pain and painful osteoarthritis following knee joint injury?
Learn about our research into the factors that predict knee pain or painful osteoarthritis in the 2 years following injury and developing a predictive tool.
Osteoarthritis - Centre for Integrated Research into Musculoskeletal Ageing
Learn about the Centre for Integrated research into Musculoskeletal Ageing (CIMA), researching why our bones, joints and muscles function less well as we age.
Osteoarthritis - Centre for Osteoarthritis Pathogenesis Versus Arthritis
Learn about our Centre for Osteoarthritis Pathogenesis - aiming to understand the processes involved in OA to identify how and why it develops and progresses.
Osteoarthritis - Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis
Learn about our Centre for Sport, Exercise and Osteoarthritis Research, where experts in sports medicine and OA identify risk factors in sport injuries.
Osteoarthritis - Comparing performance, costs and current practice for hip replacement implants
Learn about our research into to the relationship between the hip implant industry and the NHS - looking at costs, surgeon choice and current policies.
Osteoarthritis - Developing a sensor to monitor conditions in the knee following joint replacement surgery
Learn about our research into developing a sensor (iSMART) that can be incorporated into implants and track recovery by monitoring conditions such as movement.
Osteoarthritis - Developing a system for measuring hip shape to look at the best treatments for hip diseases in childhood (ORCHID)
Read more about developing a system for measuring hip shape to look at the best treatments for hip diseases in childhood (ORCHID)
Osteoarthritis - Developing a test to identify hip abnormalities in newborns, and prevent early-onset osteoarthritis
Learn more about the grant developing a test to identify hip abnormalities in newborns, and prevent early-onset osteoarthritis
Osteoarthritis - Developing an exercise programme for people over 80
Read more about developing a tailored exercise programme for people aged over 80 with hip and knee osteoarthritis.
Osteoarthritis - Developing and evaluating the use of cell implantation therapy
Learn about our research into existing therapies that use a patient’s own cells to repair damaged joint tissues, to improve and extend current techniques.
Osteoarthritis - Developing mathematical tools to understand complex data in the study of joint disease
Learn more about developing developing mathematical tools to understand complex data in the study of joint disease.
Osteoarthritis - Development of a new biological therapy for osteoarthritis
Learn more about our research into the TSG-6 protein, which prevents inflammation and tissue damage, to design clinical trials and secure partnerships.
Osteoarthritis - Development of a new screening method for potential osteoarthritis treatments
Read more about our research to develop a device based on human tissue or cells, as an alternative to animal research and drug development in osteoarthritis.
Osteoarthritis - Do lncRNAs control inflammation and joint damage in obesity related osteoarthritis?
Learn more about our research to determine whether Long non-coding RNAs (lncRNAs) control joint inflammation and damage in obesity related osteoarthritis.
Osteoarthritis - Does a molecule found in fungus hold promise for the treatment of osteoarthritis pain?
Read more about understanding if a molecule found in fungus hold promise for the treatment of osteoarthritis pain.
Osteoarthritis - Does loss of the cartilage component Fibrillin-1 contribute to osteoarthritis development?
Learn about our research which aims to better understand the role of fibrillin-1 (a protein found in joint cartilage) in normal and abnormal cartilage.
Osteoarthritis - Does loss of the cartilage component Fibrillin-1 contribute to osteoarthritis development?
Learn about our research which aims to better understand the role of fibrillin-1 (a protein found in joint cartilage) in normal and abnormal cartilage.
Osteoarthritis - Does removal of waste products by autophagy within the cells of bone and joint protect against musculoskeletal disease?
Learn more about if the removal of waste products by autophagy within the cells of bone and joint protect against musculoskeletal disease?
Osteoarthritis - Escape Pain Programme - Sports England
Learn about our Special Strategic Award research grant for osteoarthritis, from Health Innovation Network, titled Escape Pain Programme - Sports England.
Osteoarthritis - Evaluating the use of non-operative osteoarthritis treatments prior to total knee replacement: a feasibility study
Learn more about evaluating the use of non-operative osteoarthritis treatments prior to total knee replacement: a feasibility study.
Osteoarthritis - Harnessing the potential of 17-HDHA a novel biomarker of osteoarthritis pain status
Learn about our research into how the 17-HDHA molecule produces effective pain relief in rats with arthritis, and whether it can predict future OA pain levels.
Osteoarthritis - How do immune cells detect and help to repair cartilage damage?
Learn about our research which explores how mononuclear phagocytes (MNPs), which are a group of immune cells, interact with cells that help repair cartilage.
Osteoarthritis - How do serpin proteins help to protect against cartilage damage
Learn about our research into serpin - how levels and activity are altered in osteoarthritis, how they can protect cartilage, and their use as a treatment.
Osteoarthritis - Identifying a new treatment strategy for osteoarthritis: targeting the body’s response to injury
Read more about identifying a new treatment strategy for osteoarthritis: targeting the body’s response to injury.
Osteoarthritis - Identifying the role of lncRNAs in inflammatory pain of osteoarthritis
Learn about our research into the relationship between lncRNAs present in the joint lining and pain in people with knee osteoarthritis - aiding new treatments.
Osteoarthritis - Improving the quality of life of people with joint pain by targeting the stress regulator FKBP51
Learn more about improving the quality of life of people with joint pain by targeting the stress regulator FKBP51.
Osteoarthritis - Improving understanding of how stem cells can form, organise and repair joint tissues
Learn about our research which aims to improve knowledge of how stem cells can form, organise and repair joint tissues - potentially treating osteoarthritis.
Osteoarthritis - Investigating the potential of using broccoli to treat osteoarthritis
Learn about our research which involves the first clinical trial to test the benefits of eating broccoli on pain and physical function in osteoarthritis.
Osteoarthritis - Investigating the potential use of electronic-rehabilitation programmes for long-term knee pain in the UK
Read more about investigating the potential use of electronic-rehabilitation programmes for long-term knee pain in the UK
Osteoarthritis - Investigating the processes involved in cartilage destruction in osteoarthritis
Learn about our research into the process where cartilage cells take up molecules in osteoarthritis development and how impairment of LRP1 takes place.
Osteoarthritis - Investigating the role of a protein Rbfox1 in the development of osteoarthritis pain.
Learn about our research into understanding if the Rbfox1 gene, which regulates hypersensitivity, causes nerve hypersensitivity and pain in osteoarthritis.
Osteoarthritis - Mapping molecular changes within the osteoarthritis joint.
Learn about our research using new technology to identify and map biological molecules involved in the changes seen in several types of joint tissues.
Osteoarthritis - Mechanisms of musculoskeletal pain
Learn about our research into identifying nerves and mechanisms in mice, which are responsible for causing pain, to potentially create better painkillers.
Osteoarthritis - MICA: Synovial Fluid to Define Molecular Endotypes by Unbiased Proteomics in OA
Learn about our special strategic award - MICA: Synovial fluid to define molecular endotypes by unbiased proteomics in OA (STEpUP-OA), at University of Oxford.
Osteoarthritis - Pain Centre Versus Arthritis
Read about our centre of excellence for osteoarthritis and knee pain - the aims of the research, why it's important and how the findings will benefit patients.
Osteoarthritis - Primary Care Centre Versus Arthritis
Learn about our research centre aiming to match patients with appropriate treatment - support for those who can self-manage or medical team care if needed.
Osteoarthritis - PROMOTE: A trial of methotrexate to treat painful knee osteoarthritis
Learn about our clinical study of whether methotrexate is effective treatment for reducing pain in people with knee osteoarthritis (OA) compared to a placebo.
Osteoarthritis - Reducing infections of bone implants for people with arthritis
Learn about our research in reducing the risk of infection from joint replacement surgery, with a substance inspired by the way edible mussels attach to rocks.
Osteoarthritis - Repurposing AMP367 to prevent post-traumatic osteoarthritis
See the details about our Translational Study Full Application grant at Cardiff University - Repurposing AMP367 to prevent post-traumatic osteoarthritis.
Osteoarthritis - Role of the nerve protein TRPC5 in the development of pain and inflammation in osteoarthritis
Read more about the role of the nerve protein TRPC5 in the development of pain and inflammation in osteoarthritis.
Osteoarthritis - Role of the nerve protein TRPM3 in the development and maintenance of pain in osteoarthritis
Learn more about the role of the nerve protein TRPM3 in the development and maintenance of pain in osteoarthritis.
Osteoarthritis - Supported self-management for people living with musculoskeletal pain
Learn about our research into understanding why some people manage their pain better than others - to propose a plan to ensure support is available to everyone.
Osteoarthritis - Suramin - a new hope for blocking osteoarthritic cartilage loss?
Learn about our research into developing a treatment, based on the drug suramin, that protects cartilage from breaking down in osteoarthritis patients.
Osteoarthritis - Targeting body clocks in joint cartilage towards therapies for osteoarthritis
Learn about our research into whether changes in the setting of our body clock are linked to the damage to joint cartilage seen in osteoarthritis (OA).
Osteoarthritis - Targeting pain through Proteinase Activated Receptor 2
Learn about our research into the feasibility of targeting a protein called Proteinase activated receptor 2 (PAR2) for the treatment of osteoarthritis pain.
Osteoarthritis - Targeting the cell-signalling protein lymphotactin as a novel pain relief strategy for osteoarthritis
Read about targeting the cell-signalling protein lymphotactin as a novel pain relief strategy for Osteoarthritis
Osteoarthritis - The application of Raman arthrospectroscopy for intra-operative mapping of early articular cartilage degeneration
Learn more about the application of Raman arthrospectroscopy for intra-operative mapping of early articular cartilage degeneration.
Osteoarthritis - The PRELIM initiative: Improving musculoskeletal health intelligence
Learn about our research into the use of primary care electronic health records and patient collected data in a system to describe the status of UK MSK health.
Osteoarthritis - The role of agrin in the cause and treatment of osteoarthritis
Learn about our research into the loss of agrin (a cartilage and nerve molecule) and osteoarthritis, the contribution to nerve invasion and cartilage breakdown.
Osteoarthritis - The role of gender, menopause and sex hormones in hand osteoarthritis
Learn about our research into understanding the impact that gender, menopause and sex hormones have on the duration and severity of hand osteoarthritis.
Osteoarthritis - The role of microRNAs in osteoarthritis
Learn about our research into the role of microRNAs (molecules in the body that control the way that genes are switched on and off) in osteoarthritis.
Osteoarthritis - The role of the nerve growth mediator semaphorin 3A in joint pain
Learn about our research into semaphorin-3A, if a reduction in the joint leads to uncontrolled local nerve ingrowth and pain, and if this can be reversed.
Osteoarthritis - The usefulness of thumb splinting for people with thumb base osteoarthritis - OTTER II
Learn about our research which aims to investigate the benefit of thumb splints for people with thumb base osteoarthritis, as their effectiveness is un-known.
Osteoarthritis - Tissue Engineering & Regenerative Therapies Centre Versus Arthritis
Learn about our Tissue Engineering and Regenerative Therapies Centre, where leading academic clinicians aim to regenerate fully functional and pain-free joints.
Osteoarthritis - Understanding how changes in molecular structure affect cartilage health and repair
Learn about our research into the role of sulfations in cartilage health and repair for osteoarthritis, comparing osteoarthritic and healthy donor tissue.
Osteoarthritis - Understanding how molecules involved in healing produce pain relief in osteoarthritis
Read about our research, which aims to understand how molecules involved in healing produce pain relief in osteoarthritis.
Osteoarthritis - Understanding how TSG-6 protein contributes to the natural protection of joint tissues against osteoarthritis.
Read about understanding how TSG-6 protein contributes to the natural protection of joint tissues against osteoarthritis.
Osteoarthritis - Understanding the role bone marrow lesions play in osteoarthritis pain
Learn about our research into the development of bone marrow lesions, how their growth changes due to joint instability, and how they link to the onset of pain.
Osteoarthritis - Understanding the role of specific joint cells in localised joint pain and inflammation to develop targeted treatments
Read about our research, which aims to understand the role of specific joint cells in localised joint pain and inflammation to develop targeted treatments.
Osteoarthritis - Understanding what causes common hand conditions
Learn about our research into understanding the causes of hand osteoarthritis and carpal tunnel syndrome, two common causes of hand pain and numbness.
Osteoarthritis - Using bone marrow stem cells to produce high quality cartilage
Learn about our research into finding the best environment in which high quality cartilage, lost through osteoarthritis, can be produced from stem cells.
Osteoarthritis - Using illusions to explore brain processes in people with musculoskeletal pain
Learn about our research project which aims to better understand body perception disturbance, to reduce pain in people with musculoskeletal pain in their hands.
Osteoarthritis - Using mathematical models to identify brain changes in people with chronic pain
Learn how our research aims to find ways of measuring brain changes in people with chronic pain - who have differences in how their brain filters pain.
Osteoarthritis - Using osteoarthritis genetics to restore healthy joint cartilage
Learn about our research which is using the latest discoveries from the arcOGEN study to reveal how osteoarthritis DNA changes can improve treatments.
Osteoarthritis - Using zebrafish to track changes in cells which lead to osteoarthritis of the spine
Learn about our research using zebrafish as a new animal model to study spinal conditions and understand how specific genes cause spinal osteoarthritis.
Osteoarthritis - Walk with Ease UK – developing a community-based walking programme for adults with arthritis and musculoskeletal conditions
Learn more about Walk with Ease UK – developing a community-based walking programme for adults with arthritis and musculoskeletal conditions.
Osteonecrosis - Targeting blood vessel growth to improve bone repair
Learn about our research into the role of a blood vessel attracting molecule, Vascular Endothelial Growth Factor (VEGF), in bone loss during osteoporosis.
Osteopetrosis - Mapping phenotypic to genetic variability in the High Bone Mass Study
Learn about our research into identifying HBM-causing genes and establishing their effect on specific bone characteristics such as shape, density and function.
Osteoporosis - Can targeting damage related proteins released at the time of injury enhance fracture healing in osteoporotic bone?
Read more about can targeting damage related proteins released at the time of injury enhance fracture healing in osteoporotic bone?
Osteoporosis - Developing a screening checklist to identify women with back pain due to potentially undiagnosed fractures
Learn more about developing a screening checklist to identify women with back pain due to potentially undiagnosed fractures.
Osteoporosis - Does the beneficial effect of maternal gestational vitamin D supplementation on neonatal bone mass persist into childhood?
Learn about the beneficial effect of maternal gestational vitamin D supplementation on neonatal bone mass persist into childhood.
Osteoporosis - Improving hip fracture care in England and Wales
Learn about our research into which processes within the hip fracture healthcare pathway result in improved patient outcomes and cost-effective service.
Osteoporosis - Improving hip fracture care in England and Wales
Learn about our research into which processes within the hip fracture healthcare pathway result in improved patient outcomes and cost-effective service.
Osteoporosis - The role of the media in influencing perceptions of osteoporosis and its treatment
Learn about our research into understanding how osteoporosis and its treatment is covered in the media, and how this affects people with the condition.
Osteoporosis - Understanding and improving osteoporosis diagnosis and treatment in primary care
Read about our research, which aims to understand and improve osteoporosis diagnosis and treatment in primary care.
Osteoporosis - Understanding the role of genes in osteoporosis for the development of new treatments
Learn about our research into zebrafish to see how bone growth can change in response to gene changes and develop a method to look for osteoporosis treatments.
Osteoporosis - VERDICT: Using the computer to better identify spine fractures
Learn about our research which aims to develop a standard computerised approach to reliably detect and analyse spinal fractures in patients with osteoporosis.